Most of the people around the world suffer from depression and nervousness. The treatments related to these disorders suffer from major problems, such as a very low rate of reaction, slow onset of therapeutic effects and serious side effects. Interestingly, antidepressants like Tianeptine and Etizolam has revealed some promising results for sleep and anxiety disorder.
There may be enhanced sedation when had with medicines like beta-blockers, antibacterials, antifungals, and antipsychotics.
Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in treating irritable bowel syndrome.
What are the components?
Etizolam is a thieno diazepine that’s chemically associated with benzodiazepine (BDZ) drug class; it differs from BDZs in using a benzene ring replaced with a thiophene ring. While Tianeptine is categorized as a tricyclic antidepressant (TCA), but it possesses distinct pharmacological properties than normal tricyclic antidepressants.
Mode of Action?
Etizolam functions as an antagonist into the GABA-A receptors that subsequently prevents GABAergic transmission through the central nervous system. Etizolam actually operates on the fundamental spinal cord and creates a powerful muscle relaxant effect.
In the case of Tianeptine, it’s effective in reducing depressive symptoms in mild to severe major depressive disorder and also alleviates stress symptoms associated with depression without the necessity for coadministration of anti-anxiety medication. Tianeptine reduces the hypothalamic-pituitary-adrenal reaction to stress and consequently prevents stress-related behavioral troubles.
Etizolam can also be used for situational stress symptoms such as panic attacks or phobic neurosis. It’s also used to treat anxiety and short term sleeplessness. GABA suppresses the strange and excessive activity of the nerve cells in mind, Etizolam increases this activity of GABA and acts as an anxiolytic, sedative-hypnotic, and antidepressant, and may be used to deal with depression and other disorders.
Whereas Current research indicates that tianeptine produces its antidepressant effects through the modulation of glutamate receptor activity (for example, AMPA receptors and NMDA receptors) and affect the discharge of brain-derived neurotrophic factor (BDNF), which impacts neural plasticity.
Etizolam remains from the body for 6-8 hours although higher doses may last longer.
Tianeptine’s elimination half-life is 2.5 to 3 hours whereas the removal half-life was discovered to be increased to 4 to 9 hours at the elderly.
Cost and availability
These drugs are used by many people for sleep and anxiety. It is frequently bought online. You can buy Etizolam and Tianeptine online.
Tianeptine contains side effects like stressed mood, bipolar manic episodes, irritability, nausea, constipation, abdominal pain, headaches, dizziness, and changes in dreaming.
Drowsiness, Sleepiness, Muscle weakness, Vertigo, Headache, Confusion, Slurred speech, Change in libido, Uncontrolled shaking of arms or legs, Visual disturbances, Urinary retention/incontinence, Stomach discomfort, and pain are caused by Etizolam.